Disease Associations
* Multiple disease associations, including cancer, infection, liver disease and iron overload syndromes; this laboratory test alone is non-specific.
* Adult-onset Still’s disease (AOSD) – but this is a rare diagnosis
* Systemic JIA

Category
Acute phase reactants/inflammatory markers/cytokines

When to Order
* Suspicion of AOSD on clinical presentation

What It Means If Markedly Elevated
* Consider infection and/or malignancy first.
* If clinical presentation fits, can consider rheumatic diseases like Still’s disease

What It Means If Normal
* Unlikely AOSD