About Systemic Lupus Erythematosus

System lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease.

  • Autoantibodies form complexes with complement and deposit within tissues
  • Multifactorial etiology: interplay between genetic, environmental, and hormonal factors
  • Predominantly affects women in childbearing years but can occur in older adults and men
  • Peak age of onset: 15-45 yo
  • Racial and gender disparities exist in terms of organ involvement, disease severity, and response to therapy
  • Reported worldwide prevalence frequencies range from 20 to 240 per 100,000 people
  • Reported worldwide incidence rates range from 1 to 10 per 100,000 person-years