Main Disease Association
Systemic lupus erythematosus (SLE)

Category
Antibody

When to Order
* If +ANA and concern for lupus erythematosus (rash concerning for lupus, alopecia, inflammatory arthritis, cytopenias, proteinuria, serositis, hematuria)

What It Means If Positive
* HIGHLY SPECIFIC for SLE

What It Means If Negative
* In patients with SLE, less likely to develop renal disease

Of Note
* Correlates with disease activity
* Associated with renal disease in patients with SLE