Main Disease Association
Sjogren’s disease

Category
Antibody

When to Order
* Dry eyes/mouth/other mucosal surfaces
* Part of SLE workup

What It Means If Positive
* Part of diagnostic criteria for Sjogren’s disease
* Also seen in SLE; increased risk for neonatal lupus in offspring

What It Means If Negative
* Doesn’t rule out Sjogren’s