Main Disease Association
Systemic sclerosis

Category
Antibody

When to Order
* Clinical signs and symptoms of systemic sclerosis

What It Means If Positive
* Monitor for development of or progression of scleroderma and systemic sclerosis disease features (including heart or lung involvement)
* U3RNP has strong association with scleroderma renal crisis

What It Means If Negative
* Doesn’t rule out scleroderma/systemic sclerosis