Main Disease Association
Systemic lupus erythematosus (SLE)

Category
Antibody

When to Order
* If +ANA and concern for lupus erythematosus (rash concerning for lupus, alopecia, inflammatory arthritis, cytopenias, proteinuria, serositis, hematuria, Raynaud’s)

What It Means If Positive
* HIGHLY SPECIFIC for SLE

What It Means If Negative
* Not sensitive

Of Note
* Named after patient in whom the targeted antigen was found: Stephanie Smith (young patient who died in her 20s due to complications from SLE).