Main Disease Associations
* Most commonly associated with ankylosing spondylitis; high correlation with anterior uveitis
* Seen with spondyloarthritis-related diseases: reactive arthritis, inflammatory bowel disease, psoriasis
* High correlation with sacroiliitis

Category
Genotypic associations

When to Order
* Suspected diagnosis of any of the spondyloarthritides, sacroiliitis, uveitis

What It Means If Normal
* Doesn’t rule out any associated conditions

What It Means If Not Normal
* High correlation with development of sacroiliitis, uveitis +/- any spondyloarthritis-related diseases. Most HLA-B27+ patients do not end up developing disease, so correlation with clinical symptoms is key.