Main Disease Association
ANCA-associated vasculitis

Category
Antibody

When to Order
* Follow-up test for c-ANCA positivity since it is a type of c-ANCA antibody

What It Means If Positive
* Strong association with granulomatous polyangiitis (GPA) – 95% specificity
* Can also be seen in MPA (but less common than P-ANCA/MPO)

What It Means If Negative
* Does NOT rule out vasculitis